Journal: Journal of process control
Article Title: A New Animal Model of Insulin-Glucose Dynamics in the Intraperitoneal Space Enhances Closed-Loop Control Performance
doi: 10.1016/j.jprocont.2019.01.002
Figure Lengend Snippet: Closed-loop robustness analysis of the proposed IP-IP controller (green) vs. the proposed IP-SC controller with subcutaneous sensing (red), and the IP-IP PID controller (black) designed by Huyett et al 24. [A] Median glucose trajectories in mg/dL with unannounced meals (inverted cyan triangles) and effect of exercise input (red triangle). Set point is at 110 mg/dL. [B] Corresponding median insulin delivery in U/5 min. [C] Comparison of the percent time in hypoglycemia (< 70 mg/dL). [D] Comparison of the percent time in glycemic safe zone (within 70–180 mg/dL). [E] Comparison of the percent time in hyperglycemia (>180 mg/dL).
Article Snippet: Ten adults (7 male, 3 female) with T1DM participated in a non-randomized, non-blinded sequential AP study ‡ using subcutaneous glucose sensing via Dexcom Seven Plus sensors (Dexcom, San Diego, USA) and zone MPC modified[ 31 ] for IP delivery via the Diaport system (Second Generation, Roche Diagnostics, Mannheim, Germany).
Techniques: Comparison